What we think is
what we become…
"Domohorn Wrinkle"

Japan's first collagen-containing skincare products

Learn from nature, ancient wisdom, and cutting-edge technology. In 1974, "Domohorn Wrinkle" was created by Saishunkan Pharmaceutical company. We are experts in Kampo and are constantly improving our products by fusing it with the most advanced science and technology.

We conducted our own research, focusing on boosting the skin's self-repairing power to keep the skin healthy and radiant regardless of age.
For that reason, Domohorn Wrinkle, created with the desire to control age-related skin degradation, brings out the skin's natural power and promotes age-resistant skin.

Learn from nature, ancient wisdom, and cutting-edge technology. In 1974, "Domohorn Wrinkle" was created by Saishunkan Pharmaceutical company. We are experts in Kampo and are constantly improving our products by fusing it with the most advanced science and technology.

We conducted our own research, focusing on boosting the skin's self-repairing power to keep the skin healthy and radiant regardless of age.
For that reason, Domohorn Wrinkle, created with the desire to control age-related skin degradation, brings out the skin's natural power and promotes age-resistant skin.

Domohorn Wrinkle conducts ongoing research and development to reduce wrinkles,
dark spots and age-related skin concerns.

Have you ever had an experience like this?

After the age of 30,
small wounds became more difficult to heal,
whereas as a child, they healed quickly.

This is because of a reduction in the skin's self-repairing power.

As we age, the ability to heal ourselves from injury decreases, and this factor also influences the appearance of wrinkles and other signs of aging skin.

That's why our aim is to strengthen the skin's self-repairing power and improve age-related problems, including wrinkles and spots.

The structure of skin problem causes is closely related to a domino effect.
If the upstream domino is not stopped at the start, falling dominoes will gradually affect downstream dominoes until all of them are down.
Each domino that falls triggers another skin problems.
The further downstream you go, the more serious your skin problems become.
No matter how well you care for your skin, if no "measures" have been taken since the beginning, a new skin problem will appear.

To stop the negative chain effect and improve the skin problems from upstream, we focus on the HSP, a protein that is naturally found in humans and keeps skin youthful with its original power, and the ANL, a protein that accelerates aging.

We have created a new approach to strengthen the HSP,
which maintains youth, and block the ANL, which speeds up aging.

The ingredient that inhibits aging-accelerating protein.

Shiranui Chrysanthemum

Suppresses age-accelerating
protein

Reduces the amount of age-accelerating protein by approximately 80%

The ingredients that boost the skin's self-repairing power protein.

Tulip

Promotes proper collagen structure and skin elasticity.
It was discovered while researching HSP47.

The role of fibroblasts

In this way, HSP47 is able to effectively produce compact
high-quality collagen.

Yabatsui

Protects cells from UV damage and was discovered while researching HSP70.

It also boosts the levels of "HSP70," which restores skin damaged by UV rays

This is how "Domohorn Wrinkle" originally came to be.
All of our 8 products were born from Kampo's concept, fusing cutting-edge science and technology to address age-related skin problems at their root cause. We continually work on research and development to delay the appearance of aging skin.

Have your best skin and keep in looking forever healthy and radiant.
No matter what gender, Domohorn Wrinkle is ideal for anyone.